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7-aza-spiro [3.5] nonane-7-carboxylic acid ester derivatives, their preparation and their therapeutic use
专利权人:
サノフイ
发明人:
アブアブデラ,アメツド,シユルズ,ナタリー,フアイヨル,オード,ロチード,アリステア,サデイ,ムラ,バツシユ,ジユリアン,イエシユ,フイリツプ,アブアブデラ,アメツド,シユルズ,ナタリー,フアイヨル,オード,ロチード,アリステア,サデイ,ムラ,バツシユ,ジユリアン,イエシユ,フイリツプ
申请号:
JP2012510342
公开号:
JP5680624B2
申请日:
2010.05.11
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
The invention relates to compounds of the general formula (I) where: R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, or NR8R9 group; m, n, o and p independently are a number from 0 to 3, provided that 2≦̸m+n≦̸5 and that 2≦̸o+p≦̸5; A is a covalent bond, an oxygen atom, a C1-6-alkylene group or a —O—C1-6-alkylene group in which the end that is an oxygen atom is bonded to the R1 group and the end that is an alkylene group is bonded to the carbon of the bicyclic compound; R1 is an optionally substituted aryl or heteroaryl group; R3 is a hydrogen or fluorine atom or a C1-6-alkyl or trifluoromethyl group; R4 is an optionally substituted 5-membered heterocyclic compounds; wherein the compounds can be in the state of a base or an acid addition salt. The invention can be used in therapeutics.
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