A tablet splitting apparatus with high practicality etc. that can be compactly mounted at a location for mounting of a tablet cassette in a medicine dispensing apparatus is provided. A rotation transmission shaft (40) that extends vertically to penetrate a box body (31) is provided. When the box body (31) is placed on a base portion (13) of a tablet feeder mounted in a medicine dispensing apparatus, a lower end portion (43) of the rotation transmission shaft (40) is coupled to the base portion (13) so as to be able to transmit rotation, and a tablet guiding mechanism (60) is coupled to a cut tablet piece receiving portion (15) of the base portion (13). When a tablet cassette (20) configured to discharge tablets housed in a random manner, one at a time, as a rotor (21) rotates is placed on the box body (31), an upper end portion (41) of the rotation transmission shaft (40) is coupled to the rotor (21) to be able to transmit rotation, and the tablet guiding mechanism (60) is coupled to a tablet discharging portion (23) of the tablet cassette (20).