Andrew Frederick Wilks;Herbert Rudolf Treutlein;Marcel Robert Kling;Michelle Leanne Styles;Xianyong Bu;Jun Zeng;Christopher John Burns
发明人:
Michelle Leanne Styles,Jun Zeng,Herbert Rudolf Treutlein,Andrew Frederick Wilks,Marcel Robert Kling,Xianyong Bu,Christopher John Burns
申请号：
US12895548
公开号：
US08329737B2
申请日:
2010.09.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C1-4 alkyl, O, S, SO2, CO or CS and X1, X2, X3 and X4 are optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) are also provided. Further provided are methods of treating tyrosine kinase-associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).
