A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C<；SUB>；1-4 <；/SUB>；alkyl, O, S, SO<；SUB>；2<；/SUB>；, CO or CS and X<；SUB>；1<；/SUB>；, X<；SUB>；2<；/SUB>；, X<；SUB>；3 <；/SUB>；and X<；SUB>；4 <；/SUB>；are optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) are also provided. Further provided are methods of treating tyrosine kinase-associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).
