compound having a structure according to formula i, pharmaceutically acceptable salt, pharmaceutical composition, method for preventing or treating a disease or condition and method for immunomodulation, inhibiting or preventing rejection of organ or skin grafts or treating tumors or cancer
the present invention provides a genus of polycyclic amines that are useful as modulators of opioid receptors. the compounds of the invention are useful in therapeutic and diagnostic methods, including for the treatment of pain, neurological disorders, cardiac disorders, intestinal disorders, drug and alcohol dependence, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, rejection graft or cancer.a presente invenção proporciona um gênero de aminas policíclicas que são úteis como moduladores de receptores de opioides. os compostos da invenção são úteis em métodos terapêuticos e de diagnóstico, incluindo para tratamento da dor, distúrbios neurológicos, distúrbios cardíacos, distúrbios intestinais, dependência de drogas e álcool, overdose de drogas, distúrbios urinários, distúrbios respiratórios, disfunção sexual, psoríase, rejeição de enxerto ou câncer.
