The present invention relates to immunotherapeutic peptides and their use inimmunotherapy, in particular the immunotherapy of cancer. The present inventiondiscloses tumour-associated T-helper cell peptide epitopes, alone or in combinationwith other tumour-associated peptides that serve as active pharmaceuticalingredients of vaccine compositions which stimulate anti- tumour immune responses.In particular, the composition of the peptides of the present invention can beused in vaccine compositions for eliciting anti-tumour immune responses againstcolorectal cancer.