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ANTIFUNGAL NYLON-3 POLYMERS AND COMBINATION THERAPY USING THEM TO TREAT FUNGAL INFECTIONS
专利权人:
发明人:
Runhui Liu,Bernard Weisblum,Samuel Gellman,Fang Yun Lim,Leslie Anne Rank,Nancy P. Keller,Jin Woo Bok,Christina M. Hull,Naomi Marie Walsh,Mingwei Huang
申请号:
US15850416
公开号:
US20180185408A1
申请日:
2017.12.21
申请国别(地区):
US
年份:
2018
代理人:
摘要:
A method and corresponding pharmaceutical composition for inhibiting the growth of fungi. The method uses an antifungal composition containing as the active ingredient one or more nylon-3 copolymers having a formula:or a salt thereof,wherein: each R is independently hydrogen or C1-C6-alkyl each R1, R3, R4, R5, and R6 are each independently selected from the group consisting of hydrogen or substituted or unsubstituted C1-C6-alkyl each R2 is C1-C6-alkylene “A” is hydrogen or an amino-protecting group “B” is hydroxyl or a carboxy-protecting group and “X,” “Y,” and “Z” are positive numbers.
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