The present invention relates to the medical field, and discloses a compound preparation of lercanidipine hydrochloride and atorvastatin calcium, which has a drug content per unit dosage of 5-20 mg of lercanidipine hydrochloride and 0-80 mg of atorvastatin calcium. The present invention also particularly provides a compound preparation in the form of tablets, which comprises lercanidipine hydrochloride and atorvastatin calcium as main drugs, and calcium carbonate, microcrystalline cellulose, sodium carboxymethyl cellulose, hydroxy propyl cellulose, polysorbate 80, magnesium stearate, pregelatinized starch and colloidal silicon dioxide as auxiliary materials, and opadry as a coating. A clinical test shows that the compound preparation of lercanidipine and atorvastatin calcium according to the present invention is effective in significantly reducing hypertension and lipids； the medical dose is reduced, the incidence of adverse effects is lowered, and the tolerance and drug therapy compliance of patients is good, thus the compound preparation has a good clinical application prospect.
