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КОМБИНИРОВАННЫЙ ПРЕПАРАТ ЛЕРКАНИДИПИНА И АТОРВАСТАТИНА
专利权人:
ЧЖАОКЭ ФАРМАСЬЮТИКАЛ (ГУАНЧЖОУ) КОМПАНИ ЛИМИТЕД (CN)
发明人:
ЛИ Сяои (CN),ЧЖАН Гохуэй (CN),ДАЙ Сянжун (CN),ЛИН Цзюань (CN),ХУ Дайди (CN)
申请号:
RU2015101769
公开号:
RU2015101769A
申请日:
2013.02.25
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A combined preparation lercanidipine and atorvastatin calcium, characterized in that said preparation comprises 5-20 mg of lercanidipine hydrochloride and 10-80 mg of atorvastatin calcium in unit dosage formu.2. Combined preparation according to claim 1, characterized in that the weight ratio of lercanidipine hydrochloride to atorvastatin calcium is 1:. 1-8.3. Combined preparation according to claim 1, characterized in that the weight ratio of lercanidipine hydrochloride to atorvastatin calcium is 1:. 2-4.4. Combined preparation according to claim. 1, characterized in that it contains 1-5% of lercanidipine hydrochloride, 2-20% calcium and atorvastatin 0.01-20% calcium carbonate, 10-40% microcrystalline cellulose, 10-20% sodium carboxymethylcellulose 2-8% hydroxypropylcellulose, 0.1-10% polysorbate 80, 0.5-2.5% magnesium stearate, 5-15% pregelatinized starch and 1-10% colloidal silica as auxiliary veschestv.5. Combined preparation according to claim. 4, characterized in that it uses a sugar coating of Opadry in an amount of 2-4% by combined preparata.6. The process according to obtain a combined preparation 5, characterized in that it comprises the following steps:. Stage 1: the active pharmaceutical ingredient of lercanidipine hydrochloride and the active pharmaceutical ingredient atorvastatin calcium were weighed and sieved, mixed homogeneously with calcium carbonate, microcrystalline cellulose, sodium carboxymethylcellulose , hydroxypropylcellulose, polysorbate 80, magnesium stearate, pregelatinized starch and colloidal silicon dioxide is subjected to a vacuum pressed, crushed, sieved1. Комбинированный препарат лерканидипина и аторвастатина кальция, характеризующийся тем, что указанный препарат содержит 5-20 мг лерканидипина гидрохлорида и 10-80 мг аторвастатина кальция на единичную лекарственную форму.2. Комбинированный препарат по п. 1, характеризующийся тем, что массовое отношение лерканидипина гидрохлорида к аторвастатину кальция составляет 1:1-8.3. Комбини
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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