Disclosed herein are compounds having the formula (I) wherein a dashed line represents the presence or absence of a bond； Y is an organic acid functional group, or an amide or ester thereof； or Y is hydroxymethyl or an ether thereof； or Y is a tetrazolyl functional group； A is &mdash；(CH2)6&mdash；, cis &mdash；CH2CH&boxH；CH&mdash；(CH2)3&mdash；, or &mdash；CH2C&boxH；C&mdash；(CH2)3&mdash；, wherein 1 or 2 carbon atoms may be replaced by S or O； or A is &mdash；(CH2)m&mdash；Ar&mdash；(CH2)o&mdash； wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 &mdash；CH2&mdash； may be replaced by S or O, and 1 &mdash；CH2&mdash；CH2&mdash； may be replaced by &mdash；CH&boxH；CH&mdash； or &mdash；C&equiv；C&mdash；； U1 and U2 are independently selected from &mdash；H, &boxH；O, &mdash；OH, &mdash；F, &mdash；Cl, and &mdash；CN； and B is aryl or heteroaryl, for use as acular hypotensive agent.
