Disclosed herein are compounds having formula (I) wherein a dashed line represents the presence or absence of a bond Y is an organic acid functional group, or an amide or ester thereof or Y is hydroxymethyl or an ester thereof or Y is a tetrazolyl functional group A is —(CH2)6—, cis-CH2CH═CH—(CH2)3—, or —CH2C═C—(CH2)3—, wherein 1 or 2 carbon atoms may be replaced by S or O or A is —(CH2)m—Ar—(CH2)o—, wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 —CH2— may be replaced by S or O, and 1 —CH2—CH2— may be replaced by —CH═CH— or —C≡C— U1 and U2 are independently selected from —H, ═O, —OH, —F, —Cl, and —CN and B is aryl or heteroaryl, for use as acular hypotensive agent.
