CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE

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专利权人:

HANGZHOU DAC BIOTECH CO.; LTD

发明人:

ZHAO, Robert Yongxin,HUANG, Yuanyuan,YANG, Qingliang,GAI, Shun,YE, Hangbo,ZHAO, Linyao,YANG, Chengyu,XU, Yifang,GUO, Huihui,CHAO, Minjun,TONG, Qianqian,LI, Wenjun,CAI, Xiang,ZHOU, Xiaomai,XIE, Hongshe

申请号：

PH12019502278

公开号：

PH12019502278A1

申请日:

2019.10.03

申请国别(地区):

PH

年份:

2020

代理人:

摘要：

What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent in a specific manner. It also relates to application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/