Conjugation of a cytotoxic drug with bis-linkage

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专利权人:

Hangzhou DAC Biotech Co.; Ltd

发明人:

Zhao, Robert Yongxin,Huang, Yuanyuan,Yang, Qingliang,Gai, Shun,Ye, Hangbo,Zhao, Linyao,Yang, Chengyu,Xu, Yifang,Guo, Huihui,Chao, Minjun,Tong, Qianqian,Li, Wenjun,Cai, Xiang,Zhou, Xiaomai,Xie, Hongshe

申请号：

AU2017408164

公开号：

AU2017408164A1

申请日:

2017.04.06

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent in a specific manner. It also relates to application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/