To provide pharmaceutical compositions comprising oligonucleotides which can preferably induce skipping of two or more exons of an mRNA precursor.SOLUTION: An oligonucleotide can bind to a first exon region derived from a dystrophin mRNA precursor and a second exon region in the same mRNA precursor, the region of the second exon has at least 50% identity to the region of the first exon, and the oligonucleotide is suitable for skipping the first exon and the second exon of the mRNA precursor, as well as preferably the entire stretch of exons in between the first and the second exons.SELECTED DRAWING: None
