The present invention relates to 6-amino(aza)indane compound of the formula I and the physiologically tolerated acid addition salts of these compounds. The invention also relates to pharmaceutical compositions comprising at least one compound of the formula I or a pharmaceutically acceptable salt thereof and to a method for treating a medical disorder susceptible to treatment with a dopamine D3 receptor ligand, said method comprising administering an effective amount of at least one compound of the formula I or a pharmaceutically acceptable salt thereof.本發明係關於式I之6-胺基(氮雜)氫茚化合物其中Ar 為苯基或芳香性之5-或6-員之C-鍵結之雜芳香基，其中Ar可帶1個Ra基而且其中Ar可也帶1或2個Rb基，X 為N或CH；E 為CR6R7或NR3，R1 為C1-C4-烷基、C3-C4-環烷基、C3-C4-環烷甲基-、C3-C4-烯基、氟化之C1-C4-烷基、氟化之C3-C4-環烷基、氟化之C3-C4-環烷甲基、氟化之C3-C4-烯基、甲醯基或C1-C3-烷羰基；R1a 為H，或R1a及R2或R1a及R2a一起為(CH2)n，而n為1、2、3或4；R2及R2a個別獨立地為H、CH3、CH2F、CHF2或CF3；R3 為H或C1-C4-烷基；及這些化合物之生理上可容忍之酸加成鹽。本發明亦係關於醫藥組合物，其包括至少一種式I化合物或其醫藥可接受之鹽，以及關於治療易受多巴胺D3受體配位體之治療所影響的醫學病症之方法，該方法包括施予有效量之至少一種式I化合物或其醫藥可接受之鹽。
