PASSINI Marco A.,ZIEGLER Robin J.,DODGE James,SHIHABUDDIN Lamya,CHENG Seng H.
申请号：
SI200732075
公开号：
SI1986661T1
申请日:
2007.02.08
申请国别(地区):
SI
年份:
2018
代理人:
摘要：
This disclosure pertains to methods and compositions for tolerizing a mammal's brain to exogenously administered acid sphingomyelinase polypeptide by first delivering an effective amount of a transgene encoding the polypeptide to the mammal's hepatic tissue and then administering an effective amount of the transgene to the mammal's central nervous system (CNS).
