INSTYTUT BIOLOGII MEDYCZNEJ POLSKIEJ AKADEMII NAUK
发明人:
MAGDALENA ŁUKASIAK,JAROSŁAW DASTYCH
申请号：
PL408407
公开号：
PL408407A1
申请日:
2014.06.02
申请国别(地区):
PL
年份:
2015
代理人:
摘要：
The object of the invention is a new medical application of a chromium-based formula I, in which each of R1a and R1b is a formula chosen independently of the group comprising hydrogen and phenyl, possibly based on 1-3 bases selected from the group comprising halogen, hydroxyl, C1-4 alkyl, C1-4 alkoxyl, C1-4 alkanoyloxyl； R2a and R2b denote hydrogen atoms； each R3a and R3b denotes C1-4 alkyl or R3a and R3b together denote the group of oxo or collectively denote the base of C5-8 alkylene so that, together with the carbon atom to which R3a and R3b are attached, they form a ring,where, i n the main chain of C5-8 alkylene to two non-neighbouring carbon atom s, it is replaced by nitrogen atoms and which is C5-8 alkylene, if any, is alkylene-based； n specifies the number of alkylene bases and means the total number from 1 to 3 including； z specifies the serial number of the alkylene base and total number from 4 to n+3 including； (R) means the base of the benzene ring attached to the non-carbon atom selected independently of the group comprising hydroxyl, halogen, C2-6 alkenyl, C1-4 alkoxyl, C1-4 alkanoyloxyl,heterocyclohexyl-C4-7 alkyloxyl having an oxygen atom in the ring and possibly based on 1-3 constituents selected from a group of C1-4 alkanoyloxyl, phenyl-C3-6 alkenyl, whether or not propelled in an aryl ring by C1-4 alkanoyloxyl and propelled in a chain by an oxo present in a carbon atom adjacent to a carbon atom engaged in a double bond of C=C； in the form of a tautomer, an enantiomer, a diastereomer, A compound with formula I is used as an immunosuppressive agent.Przedmiotem wynalazku jest nowe zastosowanie medyczne związku podstawionego chromami o wzorze I, w którym każdy spośród R1a i R1b oznacza podstawnik wybrany niezależnie z grupy obejmującej atom wodoru i fenyl, ewentualnie podstawiony przez 1 - 3 podstawniki wybrane z grupy obejmującej halogen, hydroksyl, C1-4 alkil, C1-4 alkoksyl, C1-4 alkanoiloksyl； R2a i R2b oznaczają atomy wodoru； każdy R3a i R3b oznac
