RIEDL, BERND,DUMAS, JACQUES,KHIRE, UDAY,LOWINGER, TIMOTHY B.,SCOTT, WILLIAM J.,SMITH, ROGER A.,WOOD, JILL E.,MONAHAN, MARY-KATHERINE,NATERO, REINA,RENICK, JOEL,SIBLEY, ROBERT N.
申请号：
ES10180762
公开号：
ES2384160T3
申请日:
2000.01.13
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Use of a compound of Formula IA-D-B (I) or a pharmaceutically acceptable salt thereof, wherein D is -NH-C (O) -NH-, A is a substituted residue with up to 40 carbon atoms of the formula: -L- (M-L1) q, wherein L is a substituted or unsubstituted phenyl or pyridinyl moiety, directly attached to D, L1 comprises a substituted phenyl, pyridinyl or pyrimidinyl moiety, M is a group of bridge that has at least one atom, q is an integer of 1-3； and B is a substituted or unsubstituted phenyl or pyridinyl group, directly attached to D, in which L1 is substituted with at least one substituent selected from the group consisting of -SO2Rx, -C (O) Rx and -C (NRy) Rz, Ry is hydrogen or a carbon-based moiety with up to 24 carbon atoms that optionally contains heteroatoms selected from N, S and O and that is optionally substituted with halo, until reaching per halo, Rz is hydrogen or a moiety based on carbon with up to 30 carbon atoms, which optionally contains heteroatoms selected from N, S and O and which is optionally substituted with halogen, hydroxy and carbon-based substituents with up to 24 carbon atoms, which optionally contain heteroatoms selected from N, S and O and which are optionally substituted with halogen； Rx is NRaRb where Ra and Rb sona) independently hydrogen, a carbon-based moiety with up to 30 carbon atoms, which optionally contains heteroatoms selected from N, S and O and which is optionally substituted with halogen, hydroxy and carbon-based substituents with up to 24 carbon atoms, which optionally contain heteroatoms selected from N, S and O and which are optionally substituted with halogen, or -OSi (Rf) 3 where Rf is hydrogen or a carbon-based moiety with up to 24 carbon atoms , which optionally contains heteroatoms selected from N, S and O and which is optionally substituted with halogen, hydroxy and carbon-based substituents with up to 24 carbon atoms, which optionally contain heteroatoms selected from N, S and O and which are optionally substituted with halo
