A nerve-stimulating and signal-monitoring device includes a flexible substrate, a modulation/demodulation module, a SOC unit and a plurality of stimulation probes. The modulation/demodulation module demodulates coded nerve-stimulating radio-frequency signals or modulates sending coded epidermal nerve response signals. The SOC unit and the modulation/demodulation module can be integrally packaged and bonded on the flexible substrate. The SOC unit decodes and transforms the coded nerve-stimulating radio-frequency signals to obtain nerve-stimulating electrical probe-driving signals. The stimulation probes protrude from the flexible substrate, are configured to transmit the nerve-stimulating electrical probe-driving signals to epidermal nerves, and are electrically coupled to the SOC unit. The SOC unit can receive, amplify, analyze, classify and encode epidermal nerve response signals sent to the modulation/demodulation module for modulating, and such coded epidermal nerve response signals are subsequently transmitted by an antenna to the monitor station for decoding, monitoring and analysis.
