SCHUNK, STEFAN,ZEMOLKA, SASKIA,LINZ, KLAUS,ENGLBERGER, WERNER,THEIL, FRITZ
申请号：
ES09713839
公开号：
ES2496215T3
申请日:
2009.02.25
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Substituted 4-aminocyclohexane derivatives of general formula I, where R1 and R2 represent, independently of one another, methyl or H, or the groups R1 and R2, together with the N atom, form a ring and together mean (CH2) 3 ； R3 means phenyl, in each case unsubstituted or monosubstituted with F, Cl, CN, CH3； thienyl； or n-butyl, unsubstituted or mono or poly substituted with OCH3, OH, OC2H5, in particular with OCH3； R4 is where A is N or CR7-10, where A is N at least once； R5, R7, R8, R9 and R10 independently represent H, F, Cl, Br, CN, CH3, C2H5, NH2, tert-butyl, Si (ethyl) 3, Si (methyl) 2 (tert-butyl), SO2CH3, C (O) CH3, NO2, SH, CF3, OH, OCH3, OC2H5 or N (CH3) 2, preferably Si (ethyl) 3, Si (methyl) 2 (tert-butyl), CN, CF3, F, C (O) CH3, SO2CH3 or CH3； and R6 represents H, CH3 or C (O) CH3. in the form of racemate； of enantiomers, of diastereomers, of mixture of enantiomers or diastereomers or of an individual enantiomer or diastereomer； of bases and / or salts of physiologically compatible acids or cations.Derivados de 4-aminociclohexano sustituidos de fórmula general I, donde R1 y R2 representan, independientemente uno de otro, metilo o H, o los grupos R1 y R2, junto con el átomo de N, forman un anillo y significan conjuntamente (CH2)3； R3 significa fenilo, en cada caso no sustituido o monosustituido con F, Cl, CN, CH3； tienilo； o nbutilo, no sustituido o mono o poli sustituido con OCH3, OH, OC2H5, en particular con OCH3； R4 es donde A es N o CR7-10, donde A es N al menos una vez； R5, R7, R8, R9 y R10 representan, independientemente, H, F, Cl, Br, CN, CH3, C2H5, NH2, tert-butilo, Si(etilo)3, Si(metil)2(tert-butil), SO2CH3, C(O)CH3, NO2, SH, CF3, OH, OCH3, OC2H5 o N(CH3)2, preferentemente Si(etilo)3, Si(metil)2(tert-butil), CN, CF3, F, C(O)CH3, SO2CH3 o CH3； y R6 representa H, CH3 o C(O)CH3. en forma de racemato； de enantiómeros, de diastereómeros, de mezcla de enantiómeros o diastereómeros o de un enantiómero o diastereómero individual； de bases y/o sales de á
