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Imidazole compounds that have pharmaceutical activity towards the sigma receptor
专利权人:
LABORATORIOS DEL DR. ESTEVE; S.A.
发明人:
CUBERES-ALTISENT, Rosa,HOLENZ, Joerg
申请号:
ES07711786
公开号:
ES2602099T3
申请日:
2007.03.05
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compounds according to formula I ** Formula ** in which R1 represents H; R2 represents H or methyl; R3 represents an unsubstituted cyclohexyl; a mono- or di-substituted phenyl with substituents independently selected from the group consisting of F, Cl, Br, I, OH; or an unsubstituted naphthyl group; R4 represents H; R5 and R6, identical or different, represent H, methyl, ethyl, cyclohexyl or benzyl; or together with the nitrogen atom that forms a bridge a piperidine, morpholine, pyrrolidine, azepane or piperazine group that is substituted or unsubstituted with substituents independently selected from the group consisting of methyl, ethyl, methoxy, ethoxy, F, Cl , Br, I, NH2, SH, OH, SO2, CF3, cyclohexyl; more preferably with substituents independently selected from the group consisting of C (O) -CH3, methyl or cyclohexyl; X represents a group C>; = O-; Y represents a nitrogen atom; m is 1; n is selected from 0 or 1; p is selected from 1, 2, 3, 4; optionally in the form of stereoisomers, preferably enantiomers or diastereomers, a racemate or in the form of a mixture of at least two of the stereoisomers, preferably enantiomers and / or diastereomers, in any mixing ratio, or a corresponding salt thereof or a corresponding solvate thereof.Compuestos de acuerdo con la fórmula I**Fórmula** en la que R1 representa H; R2 representa H o metilo; R3 representa un ciclohexilo sin sustituir; un fenilo mono- o di-sustituido con sustituyentes seleccionados independientemente entre el grupo que consiste en F, Cl, Br, I, OH; o un grupo naftilo sin sustituir; R4 representa H; R5 y R6, idénticos o diferentes, representan H, metilo, etilo, ciclohexilo o bencilo; o forman junto con el átomo de nitrógeno que forma un puente un grupo piperidina, morfolina, pirrolidina, azepano o piperazina que está sustituido o sin sustituir con sustituyentes seleccionados independientemente entre el grupo que consiste en metilo, etilo, metoxi, etoxi, F, Cl, Br, I, NH2, SH, OH, SO2, CF3, ciclohexilo; más
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