Sung Hwan Moon;Masakatsu Eguchi;Soo Jin Lee;Sung Chan Lee;Jae Uk Chung;Kwang Won Jeong;Cu Nguyen;Michael Kahn
发明人:
Sung Hwan Moon,Jae Uk Chung,Sung Chan Lee,Masakatsu Eguchi,Michael Kahn,Kwang Won Jeong,Cu Nguyen,Soo Jin Lee
申请号:
US12649161
公开号:
US08138337B2
申请日:
2009.12.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds and prodrugs for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.