WILLIAMS, SPENCER JOHN,STAPLETON, DAVID,ZAMMIT, STEVEN,KELLY, DARREN JAMES,GILBERT, RICHARD ERNEST,KRUM, HENRY
申请号：
ES07763756
公开号：
ES2505318T3
申请日:
2007.07.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound having Formula 2 in which R1 and R2, which may be the same or different, are selected from the group consisting of a C1 to C10 alkyl, C3 to C10 cycloalkyl, C3 to C10-methyl cycloalkyl, alkene of C3 to C10, C3 to C10 alkyne and a chain containing a heterocyclic or condensed ring； any of which may be optionally substituted； X1 and X2 are the same or different, and are selected from the group consisting of a bond, O, N and S； T is a single or double bond； R3 is selected from the group consisting of H, C3 to C10 alkene, C3 to C10 alkyne and a chain containing a heterocyclic or condensed ring, any of which may be optionally substituted； R4 is selected from the group consisting of H, OH, OR6, NHR6 or NR6R7； R5 is selected from the group consisting of H, NHR6, NR6R7, OR8, halogen, C3 to C10 alkene, C3 to C10 alkyne and a chain consisting of a heterocyclic or condensed ring； any of which may be optionally substituted； R6 and R7, which may be the same or different, are selected from the group consisting of H, C1 to C10 alkyl, C3 to C10 cycloalkyl, C3 to C10 cycloalkyl, C3 to C10 alkene, C3 to C10 alkyne , aryl, C5 to C20 alkylaryl, and a hydrocarbon ring containing a heterocyclic or condensed ring, any of which may be optionally substituted； R8 is selected from the group consisting of H, C1 to C10 alkyl, C3 to C10 cycloalkyl, C3 to C10 cycloalkyl, C3 to C10 alkene, C3 to C10 alkyne, aryl, C5 to C20 alkylaryl, and a hydrocarbon ring containing a heterocyclic or condensed ring, any of which may be optionally substituted； and n e an integer between 0 and 4； or pharmaceutically acceptable salts thereof； with the proviso that when X1 and X2 are both O or a bond, and one of R1 or R2 is C1 to C4 alkyl, the other of R1 or R2 is C4 to C10 alkyl, C3 to C10 cycloalkyl, C3 cycloalkyl to C10-methyl, C3 to C10 alkyne, or a chain containing a heterocyclic or condensed ring； and with the proviso that the compound is not TranilastUn compuesto que tiene la Fórmula 2 en la que R1 y
