Materials and Methods for Treatment and Diagnosis of Oxidative Stress Disorders The object of the invention pertains to materials and methods for the prevention and treatment of conditions of diseases associated with oxidative stress or a compromised reduction environment, including inflammatory bowel diseases, such as disease. of crohn's and ulcerative colitis. Another aspect of the object of the invention relates to compositions formulated for administration as an enema. In one embodiment, a composition suitable for administration as an enema comprises an effective amount of 5-wing and a steroid, such as budesonide or hydrocortisone. The object of the invention also relates to compositions formulated for oral administration. in one embodiment, the composition comprises alpha lipoic acid, and / or n-acetyl-1-cysteine (nac), and / or 1-glutamine. alpha lipoic acid may be racemic alpha lipoic acid, r-lipoic acid, or r-dihydro lipoic acid. Methods of the invention include administering compounds or compositions of the invention. In one embodiment, compounds or compositions of the invention are rectally instilled in a patient. in another embodiment, compounds or compositions are administered orally. The object of the invention also relates to methods for screening, assessing developmental risk, and / or diagnosing conditions associated with oxidative stress, such as ulcerative colitis and other inflammatory bowel disorders.materiais e métodos para tratamento e diagnóstico de distúrbios associados com estresse oxidativo o objeto da invenção pertence aos materiais e métodos para prevenção e tratamento de condições de doenças associadas com estresse oxidativo ou um ambiente de redução comprometido, incluindo doenças inflamatórias intestinais, tais como, doença de crohn e colite ulcerativa. um outro aspecto do objeto da invenção diz respeito a composições formuladas para administração como um enema. em uma modalidade, uma composição adequada para admini