Disclosed is the use of: a) a composition formulated for rectal administration as an enema or suppository in a person or animal, said composition comprising an amino salicylic acid, a steroid, a mast cell stabilizer and a short chain fatty acid and b) a composition formulated for oral administration, said composition comprising alpha lipoic acid for the manufacture of a medicament the prevention or treatment of an inflammatory bowel disorder in a person or animal in need thereof.