DELUCA, HECTOR F.,SIBILSKA, IZABELA K.,SICINSKI, RAFAL R.,PLUM, LORI A.
申请号：
CA2991260
公开号：
CA2991260A1
申请日:
2016.07.26
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Disclosed are 2-methylene analogs of vitamin D3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1a-hydroxy-2-methylene-vitamin D3, (20S)-1a-hydroxy-2-methylene- vitamin D3, and (5E)- 1a,25-dihydroxy-2-methylene- vitamin D3, their biological activities, and various pharmaceutical uses for these compounds including methods of treating and/or preventing bone diseases and disorders.
