PROBLEM TO BE SOLVED: To provide a medicine for reducing a myocardial infarct area which is used in the early stages of myocardial infarct after onset and contains donepezil, cholinesterase inhibitor, or its pharmaceutically acceptable salt as an active ingredient so that the medicine is given to a subject in the early stages of myocardial infarct after onset in combination with reperfusion therapy to activate the vagus nerve, to improve the hearts function, to prevent remodeling of the heart, and to reduce a myocardial infarct area.SOLUTION: A medicine for reducing a myocardial infarct area is used in the early stages of myocardial infarct after onset and contains donepezil or its pharmaceutically acceptable salt as an active ingredient.SELECTED DRAWING: Figure 5COPYRIGHT: (C)2016,JPO&INPIT【課題】コリンエステラーゼ阻害薬であるドネペジル又はその薬学的に許容可能な塩を有効成分とする心筋梗塞発症初期用心筋梗塞縮小薬を提供し、これを心筋梗塞発症後初期の被験体に投与し、再潅流療法と組み合わせることで迷走神経を活性化させ、心臓の機能を改善し、心臓リモデリングを予防し、且つ心筋梗塞領域を縮小させること。【解決手段】ドネペジル又はその薬学的に許容可能な塩を有効成分とする、心筋梗塞発症初期用心筋梗塞縮小薬とする。【選択図】図5
