BULIK-SULLIVAN, Brendan,BOUCHER, Thomas, Francis,YELENSKY, Roman
申请号：
AU2018348165
公开号：
AU2018348165A1
申请日:
2018.10.10
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
A method for identifying neoantigens that are likely to be presented on a surface of tumor cells of a subject. Peptide sequences of tumor neoantigens are obtained by sequencing the tumor cells of the subject. The peptide sequence of each of the neoantigens is associated with one or more k-mer blocks of a plurality of k-mer blocks of the nucleotide sequencing data of the subject； The peptide sequences and the associated k-mer blocks are input into a machine- learned presentation model to generate presentation likelihoods for the tumor neoantigens, each presentation likelihood representing the likelihood that a neoantigen is presented by an MHC allele on the surfaces of the tumor cells of the subject. A subset of the neoantigens is selected based on the presentation likelihoods.
