KIM, Hyo-Soo,김효수,YANG, Han-Mo,양한모,KIM, Ju-Young,김주영,LEE, Joo-Eun,이주은
申请号：
KRKR2017/008978
公开号：
WO2018/034519A1
申请日:
2017.08.17
申请国别(地区):
WO
年份:
2018
代理人:
摘要：
The present inventors completed the present invention by performing formal research in order to promote differentiation efficiency of stem cell-derived cardiac muscle cells and enhance the maturation level of the same and, as a result, and confirming that, in a group treated with NecroX, the efficiency of differentiation into stem cell-derived cardiac muscle cells is increased and more mature cardiac muscle cells can be obtained in a short period of time. According to the present invention, the stem cell-derived cardiac muscle cells treated with NecroX have a larger and thicker cell size compared to those of control groups, are strong, and display a dense actin structure, thereby indicating that stem cell-derived cardiac muscle cells induced through NecroX treatment can be prepared into cardiac muscle cells with increased maturation level, and thus when NecroX is treated, the differentiation of stem cell-derived cardiac muscle cells can be induced with high efficiency and high purity. Therefore, it is expected that NecroX of the present invention is helpful as a useful material, which can also increase the differentiation efficiency and maturation level of other differentiated cells, for the preparation of a heart disease model by establishing cardiac muscle cell differentiation from patient-specific induced pluripotent stem cells.Les présents inventeurs ont élaboré la présente invention en effectuant une recherche formelle afin de favoriser lefficacité de différenciation de cellules de muscle cardiaque dérivées de cellules souches et daméliorer le niveau de maturation de celles-ci et, en conséquence, et en confirmant que, dans un groupe traité avec NécroX, lefficacité de la différenciation en cellules de muscle cardiaque dérivées de cellules souches est augmentée et des cellules de muscle cardiaque plus matures peuvent être obtenues en une courte période de temps. Selon la présente invention, les cellules de muscle cardiaque dérivées de cellules souches traitées av
