1:1, 2:1 OR 3:1 COMPLEX CONSISTING OF A CYCLODEXTRIN OR CYCLODEXTRIN DERIVATIVE AND A HALOGENATED ETHER, PRODUCTION THEREOF AND USE THEREOF AS SOPORIFIC
BUSOLD MARKUS,부졸트 마르쿠스,MITTERWEGER SIMONE,미터베거 지모네,REGIERT MARIA ELISABETH,레기르트 마리아-엘리자베트,SIGL HARALD,지글 하랄트
申请号：
KR1020110098087
公开号：
KR1020120047762A
申请日:
2011.09.28
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A complex containing cyclodextrin or cyclodextrin derivative and low molecular halogenated ether is provided to enable controlled release of narcotic and to be used as a somnifacient. CONSTITUTION: A complex contains cyclodextrin or cyclodextrin derivative and low molecular halogenated ether mixed in a ratio of 1:1, 2:1, or 3:1. The halogenated ether has 4 or less of carbon atoms and is sevoflurane, isoflurane, or desflurane. The cyclodextrin is alpha, beta, or gamma-cyclodextrin. The cyclodextrin is methyl, sulfobutyl ether, and hydroxypropyl derivative of the alpha, beta, or gamma cyclodextrin. A method for preparing the complex comprises: a step of mixing an aqueous formulation and halogenated ether in a ratio of 4:1-35:1； a step of charging the aqueous formulation； and a step of adding halogenated ether. A pharmaceutical composition contains the complex and is manufactured in the form of tablet, coated tablet, or aqueous formulation.본 발명은 몰비 1:1 또는 2:1 또는 3:1의 시클로덱스트린 또는 시클로덱스트린 유도체 및 저분자량 할로겐화 에테르로 이루어진 복합체에 관한 것이다.
