A blood pressure measurement device is disclosed. The blood pressure measurement device includes a case, a first electrode and a stress sensor. The case includes a first surface and a second surface. The first electrode is disposed on the first surface, and the stress sensor is disposed on the second surface. The blood pressure measurement device is operated on a part of body of a user. The part of the body has a blood vessel inside. As measuring the blood pressure, the first electrode, the stress sensor and blood vessel at least partially overlap in one projection orientation. Therefore, the stress sensor is able to be pressed on the part of the body by the touch of the users on the first electrode. The present invention discloses a method of blood pressure measurement as well.本發明揭露一種血壓量測裝置包括一殼體、一第一電極、一壓力感測單元。殼體具有一第一表面及一第二表面,第一電極設置於第一表面,以及壓力感測單元設置於第二表面。其中血壓量測裝置係於一使用者的一身體部位上操作,身體部位內有一血管,當量測血壓時,第一電極、壓力感測單元以及血管在同一投影方向上至少部分重疊,使使用者接觸第一電極時,壓力感測單元能貼壓身體部位。本發明另揭露一種血壓量測方法。2‧‧‧量測裝置22‧‧‧第一電極23‧‧‧壓力感測單元24‧‧‧第二電極25‧‧‧處理單元26‧‧‧電位差量測單元27‧‧‧儲存單元28‧‧‧顯示單元