582647 Disclosed herein is the use of at least one derivative of 3,5-seco-4-norcholestane oxime corresponding to formula I, wherein the variables are defined in the specification for the manufacture of an antioxidant composition for the treatment or prevention of cosmetic conditions caused by damage from free radicals. Specifically wherein the derivative of 3,5-seco-4-norcholestane oxime is chosen from: 3,5-seco-4-norcholestan-5-one oxime-3-ol, 3,5-seco-4-norcholestan-5-one oxime-3 -methyl alcohol, or 3,5-seco-4-norcholestan-5-one oxime-3 -dimethyl alcohol.