BINGJIE SUN,CHRISTIAN HOLTZE,DAVID A. WEITZ,HO CHEUNG SHUM,YUANJIN ZHAO
申请号：
BR112014004554
公开号：
BR112014004554A2
申请日:
2012.08.15
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
patent specification: "capsule encapsulation systems and processes". The present invention relates generally to particles, including drug delivery particles and other applications. certain aspects of the invention are generally directed to particles comprising a shell and an interior at least partially contained by the shell. In some embodiments, the particles may be treated to increase retention inside, for example, to reduce the transport of an agent into or out of the interior. Such particles may exhibit greater ability to encapsulate agents and / or longer storage life (e.g. due to reduced leakage). for example, in certain embodiments, any defects such as cracks, pores, etc. within the enclosure may be sealed or otherwise treated to reduce transport therewith, for example with a solid. In some embodiments, for example, a first reagent within a particle may contact a second reagent outside the particle to form a solid or other suitable product. The enclosure may also be treated, for example, at a later point in time to cause the release of an agent contained within, in certain respects. for example, the shell may be heated to cause release of the agent from the particle or the shell may be exposed to chemical or enzymatic degradation or a change in osmolarity to cause release of an agent. Still other aspects of the present invention are generally directed to processes for producing or using such particles, kits or devices including such particles or the like.resumo patente de invenção: "sistemas e processos para encapsulamento de cápsulas". a presente invenção refere-se de forma geral a partículas, incluindo partículas para fornecimento de fármacos e outras aplicações. certos aspectos da invenção são geralmente direcionados a partículas que compreendem um invólucro e um interior pelo menos parcialmente contido pelo invólucro. em algumas modalidades, as partículas podem ser tratadas para aumentar a retenção do interior, por exemplo, para reduzir o transporte de um
