5- (2-{[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1- (R) -hydroxyethyl) -8-hydroxyquinoline- as a β2 adrenergic receptor agonist Novel polymorphic crystalline form of 2 (1H) -onheminapadisilate

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专利权人:

アルミラル・ソシエダッド・アノニマ

发明人:

ヘンマ・アマト・メストレス,エルビラ・バラゲル・アルダヌイ,フランセスク・カレラ・カレラ,イオランダ・マルチュエタ・エレウ,エンリケ・モイェス・バルス

申请号：

JP2015500862

公开号：

JP6134377B2

申请日:

2013.03.15

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention is directed to novel polymorphic crystal forms of a 5-{2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisylate. The invention is also directed to pharmaceutical compositions comprising said polymorphic crystal forms, methods of using them to treat respiratory diseases associated with ²2 adrenergic receptor activity and a process for preparing such polymophic crystal forms.

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