NOVEL POLYMORPHIC CRYSTAL FORMS OF 5-(2-{[6-(2,2-DIFLUORO-2-PHENYLETHOXY)HEXYL]AMINO}-1-(R)-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE, HEMINAPADISYLATE AS AGONIST OF THE �2 ADRENERGIC RECEPTOR.

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专利权人:

ALMIRALL; S.A.

发明人:

AMAT MESTRES, GEMMA,BALAGUER ARDANUY, ELVIRA,CARRERA CARRERA, FRANCESC,MARCHUETA HEREU, IOLANDA,MOYES VALLS, ENRIQUE

申请号：

PH12014502097

公开号：

PH12014502097A1

申请日:

2014.09.22

申请国别(地区):

PH

年份:

2014

代理人:

摘要：

The present invention is directed to novel polymorphic crystal forms of a 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisylate. The invention is also directed to pharmaceutical compositions comprising said polymorphic crystal forms, methods of using them to treat respiratory diseases associated with �2 adrenergic receptor activity and a process for preparing such polymophic crystal forms.

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