The present invention provides a compound represented by Formula (II): wherein R 1 is a chlorine atom, a fluorine atom, a methyl group or an ethynyl group； Ar is a group represented by the following Formula (a), Formula (b), Formula (c) or Formula (d): wherein R 2 is a C 1-6 alkyl group which may be substituted with one or more halogen atoms, a C 1-6 alkoxy group which may be substituted with one or more halogen atoms, a C 1-3 alkylthio group, a halogen atom, a C 1-3 alkylcarbonyl group or a C 2-5 alkynyl group which may be substituted with -OR 4 ； R 3 is a hydrogen atom or a C 1-3 alkyl group； R 4 is a hydrogen atom or a C 1-3 alkyl group； provided that Ar is a group represented by Formula (a) when R 1 is a fluorine atom, methyl group or an ethynyl group, and that R 2 is methoxy group, an ethoxy group, an isopropyl group, a propyl group, a trifluoromethyl group, a trifluoromethoxy group, 2-fluoroethyl group or 1-propynyl group when R 1 is a methyl group or a pharmaceutically acceptable salt or a solvate thereof and a pharmaceutical agent, a pharmaceutical composition and so on comprising the compound.根據本發明可提供以下式(II)所示化合物，或做為醫藥可被容許之其鹽或其媒合物，以及含該化合物之醫藥、醫藥組成物等者，[式中R1係氯原子、氟原子、甲基或乙炔基；Ar係示以下式(a)、式(b)、式(c)或式(d)所示基；R2係可被1以上之鹵素原子所取代之C1－6烷基，可被1以上之鹵素原子所取代之C1－6烷氧基、C1－3烷硫基、鹵素原子、C1－3烷羰基、或可被－OR4所取代之C2－5炔基；R3係氫原子或C1－3烷基；R4係氫原子或C1－3烷基；惟R1為氟原子、甲基或乙炔基時，Ar係式(a)所示基；且R1為甲基時，R2係甲氧基、乙氧基、異丙基、丙基、三氟化甲基、三氟化甲氧基、2－氟化乙基、或1－丙炔基]。
