GEORGE, RAJAN,TYRRELL, LORNE,NOUJAIM, ANTOINE,WANG, DAKUN,MA, ALLAN
申请号：
CA2534911
公开号：
CA2534911C
申请日:
2004.08.06
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed herein are compositions and methods for eliciting immune responsesagainst antigens. In particular, the compounds and methods elicit immuneresponses against foreign antigens that are otherwise recognized by the hostas "self~ antigens, thus breaking host tolerance to those antigens. Presentingthe host immune system with a chimeric antigen comprising an immune responsedomain and a target binding domain, wherein the target binding domaincomprises an antibody fragment, enhances the immune response against theforeign or tolerated antigen. Antigen presenting cells take up, process, andpresent the chimeric antigen, eliciting both a humoral and cellular immuneresponse against the desired antigen.
