Systems and methods are provided for utilizing depth from volume rendering for 3D printing. Three-dimensional (3D) mesh data may be generated based on one or more volume rendered images and/or volumetric datasets corresponding thereto, obtained during medical imaging (e.g., based on echo ultrasound signals during ultrasound imaging). Generating the 3D mesh data may comprise computing a plurality of depth values, where each depth value corresponds to a particular voxel in the volumetric medical imaging datasets. The 3D mesh data may be configured to enable producing a physical volume representation of one or more objects and/or structures in the one or more volume rendered images. Thus, the 3D mesh data may be used for 3D printing. For example, 3D printing data may be generated based on the 3D mesh data. The 3D printing data may be configured and formatted based on a pre-defined 3D printing standard or file format.
