The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.本發明涉及可用於在哺乳動物中進行治療和/或預防之藥物試劑,並且具體來說涉及NF-κB誘導之激酶(NIK,也稱為MAP3K14)之抑制劑,該等抑制劑可用於治療如下疾病,如:癌症、發炎性病症、代謝失調以及自身免疫疾病。本發明還針對包含此類化合物之藥物組成物;針對製備此類化合物和組成物之方法;並且針對此類化合物或藥物組成物用於預防或治療疾病之用途,該等疾病如癌症、發炎性病症、包括肥胖和糖尿病的代謝失調以及自身免疫疾病。
