SU, WEI-GUO,苏 慰国,蘇 慰國,DAI, GUANGXIU,戴广袖,戴廣袖,ZHANG, WEIHAN,张维汉,張維漢,DENG, WEI,邓伟,鄧偉,苏 慰国,蘇 慰國
申请号:
TW104131565
公开号:
TW201612181A
申请日:
2015.09.24
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
This disclosure provides novel imidazopyridazine compounds of formula (I) and pharmaceutical acceptable salt thereof, pharmaceutical compositions containing them, a process for preparing them, and their practical effect in inhibiting PI3K and potential use in treating a disease responsive to inhibition of PI3K, for example, an inflammatory disease, autoimmune disease or cancer.本發明提供了式(I)的咪唑并嗒類化合物、其藥學上可接受的鹽、其藥物組合物和其製備過程,以及它們抑制PI3K的實際效果及在治療對抑制PI3K有回應的疾病,例如炎症性疾病、自身免疫性疾病或癌症中的潛在用途。