Requirement 1: a compound of structural formula (1),And pharmaceutically acceptable salts, wherein R1 from the hydrogen group and q-c (= O) -,RZA r83099 is selected independently by hydrogen, D, hydrogen Xi, F, Cl, Br, CN, no.832209；1. Lease land No. c833218331 and 832626；cycloalkyl C₃₋₈,C₁₋₆ alkoxy,carboxi alcoxi C carbonilo amino acil C amino amido alquil C amido dialquil C amido alquil C sulfonilamino haloalquilo Cperhaloalkyl C₁₋₆,perhaloalkoxy C₁₋₆,1. C8332121 asphalt；Cilt alkylthioalkyl,alkyl C₁₋₆sulfonyl, cycloalkyl C₃₋₈sulfonyl, arylsulfonyl, arylalkylsulfonyl, heteroarylsulfonyl, heteroarylakylakylsulfonyl, alkyl C₁₋₆sulfonamido, N, N-dialkyl C₁₋₆sulfonamido, heteroaryl, aryl, aryl, alkyl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl, aryl. heterocycloalkyl, heterocycloalkoxy, and QC (= O) -,Any one of them can be replaced optionally； or two R1 parts,Any contiguous R² or R³ may combine together with the atoms to which they are attached and join to form an optionally substituted 5-8 membered heterocycloalkyl ring； when one of R⁶ or R⁷ is hydrogen, the other is independently selected from the group consisting of alkyl C₁₋₆sulfinyl, alkyl C₁₋₆sulfinylalkyl, alkenyl C₂₋₆sulfinyl, alkynyl C₂₋₆sulfinyl, cycloalkyl C₃₋₈sulfinyl, cycloalkenyl C₅₋ Finsulfinyl, arylsulfinyl, arylalkylsulfinyl, arylalkenylsulfinyl, heteroarylsulfinyl, heteroarylalkylsulfinyl, heteroarylalkenylsulfinyl, and heterocycloalkylsulfinyl,a. Any part can be replaced； or r8310a and r8311a parts can be combined with the atoms attached to them to form a ring containing a sulfur part composed of 5 to 8 replacement members；Q is r831222Or831222,NHR831222,O No. 831222； r8313；R⁸ and R⁹ are independently selected from the group consisting of hydrogen, C₁₋₁₂ alkyl,C₂₋₁₂ alkenyl,C₂₋₁₂ alkynyl,cy
