University of Maryland, Baltimore;The United States of America as Represented by the Department of Veterans Affairs
发明人:
J. Marc Simard
申请号：
US15179696
公开号：
US20170333454A1
申请日:
2016.06.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular NCCa-ATP channel and include, for example, inhibitors of SUR1 and/or inhibitors of TRPM4. Kits for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury, are also provided. The present invention also concerns treatment and/or prevention of intraventricular hemorrhage in infants, including premature infants utilizing one or more inhibitors of the channel is provided to the infant, for example to brain cells of the infant.
