Douglas S. Kim,Loren L. Looger,Eric R. Schreiter,Karol Svoboda
申请号：
US14974483
公开号：
US20160176931A1
申请日:
2015.12.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Protein indicators useful for calcium imaging, in particular, red genetically-encoded calcium indicators (GECIs) disclosed herein rival best-of-class green GECIs in terms of sensitivity for detecting neural activity, and can be monitored in vivo. The presently-disclosed subject matter further includes a method of monitoring cell activity comprising stimulating a cell comprising a red GECI polypeptide and detecting fluorescence emitted by the cell.
