ГРОССМАН Уилльям Дж. (US),ЭНТОНИСЭМИ Мэри А. (US),УОЛШ Ричард М. (US),НЕЛЬСОН Мариана И. (US),БОУЗ Нандита (US),ДЭНИЭЛСОН Майкл Э. (US),МИЧЕЛ Кайл С. (US)
申请号：
RU2014148155
公开号：
RU2014148155A
申请日:
2013.03.14
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A composition comprising: a soluble β-glucan component an antibacterial component that specifically binds to soluble β-glucan. The composition of claim 1, wherein the soluble β-glucan is derived from yeast. A composition according to claim 1 or 2, wherein the soluble β-glucan contains β-1,3 / 1,6 glucan. A composition according to claim 1 or 2, wherein the soluble β-glucan contains β (1,6) - [poly (1,3) -D-glucopyranosyl] -poly-β (1,3) -D-glucopyranose. . A composition according to claim 1 or 2, wherein the antibody component comprises a monoclonal antibody that specifically binds to soluble β-glucan. The composition of claim 5, wherein the monoclonal antibody comprises BfD I, BfD II, BfD III or BfD IV.7. A composition according to claim 1 or 2, wherein the soluble β-glucan component and the antibody component are in the same composition. A composition according to claim 1 or 2, in which the soluble β-glucan component and the antibody component are in different compositions. A composition according to claim 1 or 2, which further comprises an antitumor antibody. A method comprising co-administering to a subject a soluble β-glucan and a preparation of antibodies or an antibody component that specifically binds to soluble β-glucan. A method for increasing an individuals response to immunotherapy with soluble β-glucan, the method comprising co-administering to a subject a composition comprising soluble β-glucan and an antibody preparation that specifically binds to soluble β-glucan. The method of claim 11, further comprising identifying an individual as having a low level of β-glucan binding. A method according to any one of 10-12, in which the soluble β-glucan and the antibody preparation are administered together simultaneously. A method according to any one of 10-12, in which the soluble β-glucan and the ant1. Композиция, содержащая:растворимый β-глюкановый компонент иантительный компонент, который специфично связывается с растворимым β-глюканом.2. Композиция по п
