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WAYS OF TREATMENT OF PATHOLOGICAL CONDITIONS BY ANTIBODIES WHICH ARE CONNECTED WITH A COLONY RECEPTOR OF STIMULATING FACTOR 1 (CSF1R)
专利权人:
ИНК. (US);ФАЙВ ПРАЙМ ТЕРАПЬЮТИКС
发明人:
ВОНГ Брайан (US),МАСТЕЛЛЕР Эмма (US),РИДКВИСТ Крис (US),ЗАНГИ Джеймс Аллен (US),ХАМБЛТОН Джули (US),БЕЙКЕР Кевин (US)
申请号:
RU2015111563
公开号:
RU2015111563A
申请日:
2013.08.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method of reducing an individual’s level of at least one, at least two, at least three, or at least four, at least five, at least six, at least seven, at least eight, at least nine or at least ten factors selected from IL-6, IL-1β, IL-8, CCL2, CXCL10, TNF-α, CCL7, CXCL5, CXCL9, CXCL6, MMP-7, MMP-2 and MMP-9, comprising administering to the individual an effective amount of an antibody that binds to a colony stimulating factor 1 receptor (CSF1R), the antibody blocking the binding of colony stimulating f Ktorov 1 (CSF1) with CSF1R and blocks the binding of IL-34 with CSF1R.2. The method of claim 1, wherein the method comprises reducing the level of at least one, at least two, at least three, or four factors selected from IL-6, IL-1β, TNF-α, and CXCL10.3. The method according to p. 1 or 2, characterized in that the method includes reducing the level of IL-6.4. The method according to claim 3, characterized in that the individual has a pathological condition selected from rheumatoid arthritis, juvenile idiopathic arthritis and Castleman disease. A method according to claim 1 or 2, characterized in that the method comprises reducing the level of TNF-α. 6. The method of claim 5, wherein the individual has a pathological condition selected from rheumatoid arthritis, juvenile idiopathic arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease and ulcerative colitis. A method according to claim 1 or 2, characterized in that the method comprises reducing the level of IL-1β. The method of claim 7, wherein the individual has a pathological condition selected from rheumatoid arthritis and juvenile idiopathic arthritis. A method according to claim 1 or 2, characterized in that the method includes reducing the level of CXCL10.10. A method for the treatment of a pathological condition associated with increased1. Способ снижения у индивида уровня по меньшей мере одного, по меньшей мере двух, по меньшей мере трех или по меньшей мере четырех, по меньшей
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