The present invention relates to a composition for preventing or treating bone diseases, including as an active ingredient Guriseorin. And to promote the degradation of Runx2 protein in osteoblasts, inhibits the differentiation of osteoclasts and reduces the mRNA levels of Rankl, Guriseorin as an active ingredient of the present invention, osteoporosis is induced by administration of high-dose vitamin D I greatly alleviate the symptoms of osteoporosis in an animal model. The composition of the present invention, could be developed as a food and drug for the treatment and prevention of bone disease and the like caused by bone metastasis of cancer cells and osteoporosis is very high. [Selection Figure] Figure 5a本発明は、グリセオリンを有効成分として含む骨疾患の治療又は予防用組成物に関する。本発明の有効成分であるグリセオリンは、骨芽細胞でRunx2 タンパク質の分解を促進させ、RanklのmRNAレベルを減少させて破骨細胞の分化を抑制し、高用量ビタミンDの投与によって誘導された骨粗鬆症動物モデルで骨粗鬆症の症状を大きく緩和させる。本発明の組成物は、骨粗鬆症及びがん細胞の骨転移によって発生する骨疾患等の予防及び治療用薬物及び食品として開発される可能性が非常に高い。【選択図】図5a
