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ANTI-MUSCARINE MEDICINAL PREPARENT FREE COMPOSITION
专利权人:
КЬЕЗИ ФАРМАЧЕУТИЧИ С.П.А. (IT)
发明人:
СОЛЬЯНИ РАСКИНИ Аннамария (IT),ЛУТЕРО Эмилио (IT)
申请号:
RU2013138140/15
公开号:
RU2013138140A
申请日:
2012.02.13
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A liquid, non-propellant pharmaceutical composition intended for administration by spray and containing a compound of the general formula (I) in which R is a group of the formula (Y) in which p is 0 or an integer from 1 to 4; P is absent or is selected from the group consisting of O, S, SO, SO, and CO; W is selected from the group consisting of H, aryl and heteroaryl, where aryl and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of halogen atoms, OH, SH, NO , CN, COOH and NH; Represents Physiologists a particularly acceptable anion, said compound being dissolved in a solvent containing at least 75 vol.% water and an optional auxiliary solvent miscible with water; where the pH of the prepared solution is from 3.0 to 5.5.2. The composition of claim 1, wherein the physiologically acceptable anion A is selected from the group consisting of chloride, bromide, iodide, trifluoroacetate, formate, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate and p-toluenesulfonate. 3. A composition according to claim 1 or 2, wherein the compound of general formula (I) is present in a concentration of from 0.001 to 7 mg / ml. The composition according to claim 3, in which the concentration is from 0.005 to 5 mg / ml. The composition according to claim 4, in which the concentration is from 0.01 to 3 mg / ml. The composition according to claim 1, in which the pH is from 3.5 to 4.5.7. A composition according to claim 1, wherein the pH is adjusted using a buffer substance containing citric acid. The composition of claim 1, wherein the optional co-solvent is ethanol. The composition of claim 1, wherein the optional co-solvent is pre1. Жидкая беспропеллентная фармацевтическая композиция, предназначенная для введения путем распыления и содержащая соединение общей формулы (I)в которой Rпредставляет собой группу формулы (Y)в которой p равно 0 или представляет собой ц
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