HORN, Carsten,ZOLLNER, Sabine,METZNER, Hubert,SCHULTE, Stefan
申请号：
AU2015258240
公开号：
AU2015258240A1
申请日:
2015.11.19
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2015258240A120151210.pdf#####Abstract The present invention relates to a method for increasing the stability of a Factor VIII molecule after purification, lyophilization and reconstitution, comprising preventing proteolytic cleavage of the Factor VIII molecule into a first fragment comprising 5 essentially the Al domain and the A2 domain and a second fragment comprising essentially the A3 domain, the C1 domain and the C2 domain throughout manufacturing of the Factor VIII molecule. The invention further pertains to a method for improving the bioavailability of Factor VIII after intravenous and non- intravenous injection.
