To treat a lesion part by using a coil having a two-layer structure in which an outer coil having a large wire diameter is used outside the tip end portion of a core wire of the guide wire or an inner coil is provided in the outer coil , There is a technical problem for improving passability at the vascular occlusive lesion part while providing the distal side slowly changing low flexibility characteristic of the core wire tip part particularly when treating the diameter expansion of the vascular occlusive lesion part. SOLUTION: In a core wire distal end portion 2B of a guide wire 40, articulated frusto-conical bodies 25A to 25D in which two or more frustoconical bodies 25A to 25D whose outer diameter gradually decreases and decreases from the rear end side 2A to the distal end side 2B, 25D, the articulated frusto-conical bodies 25A to 25D have knot portions having inclination angles at the rear end and the tip of one truncated cone, and the angle of inclination toward the distal side at each node portion is By having a certain relationship, it is possible to dramatically improve the passability at the vascular occlusive lesion. (FIG.【課題】ガイドワイヤの芯線先端部の外側に、線径の大きな外側コイルを用い、又は、外側コイル内に内側コイルを設けた二層構造からなるコイルを用いて、病変部治療を行っているが、特に、血管閉塞病変部の拡径治療に際して、芯線先端部の先端側徐変低柔軟特性を備えながら、血管閉塞病変部での通過性を向上させる為の技術課題が存在する。【解決手段】ガイドワイヤ40の芯線先端部2Bに、後端側2Aから先端側2Bへ外径が徐変減少する截頭円錐体25A~25Dを2個以上連接した連接截頭円錐体25A~25Dを有し、連接截頭円錐体25A~25Dは、1個の截頭円錐体の後端と先端に、傾斜角を有する節部を備え、各節部での先端側への傾斜角が一定の関係を有することにより、血管閉塞病変部での通過性を飛躍的に向上させることができる。【選択図】図7
