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ГИДРАТ ЦИКЛОПЕПТИДНОГО СОЕДИНЕНИЯ, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО ПРИМЕНЕНИЕ
专利权人:
ШАНХАЙ ТЕХВЕЛЛ БИОФАРМАСЬЮТИКАЛ КО.; ЛТД (CN)
发明人:
ЛЮ Шидун (CN),ЧЖАН Чжаоли (CN),ВАН Сюшэн (CN),ЧЖАН Сяо (CN),ТАН Чжицзюнь (CN),ЦЗИ Сяомин (CN)
申请号:
RU2014143721
公开号:
RU2014143721A
申请日:
2013.03.29
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. The hydrate compounds of formula I wherein R is H or a cation capable of forming a pharmaceutically acceptable salt thereof, preferably wherein the water content of the hydrate more than 8 wt.%: 2. Hydrate according to claim. 2, wherein the water content is from 8 to 30 wt.%. 3. Hydrate according to claim. 3, where the water content is from 9.5 to 28.0 wt.%. 4. Hydrate according to any one of claims. 1-3, obtainable by the following steps: (a) dissolving the compound of formula I in water or a water-soluble organic solvent (i), and pH adjustment of the solution containing the compound of Formula I (b) obtaining a hydrate containing a compound of formula I, by lowering the temperature and / or adding water-soluble organic solvent (i) (c) preparation of hydrate centrifugation or filtration (d) vacuum drying the hydrate obtained in the step (c) and regulating the water content in weight percent of the solids in said di apazone.5. Hydrate according to claim. 4, wherein said organic solvent (i) is selected from C1-C4 lower spirtov.6. Hydrate according to claim. 5, wherein the lower alcohol is one or more alcohols selected from the group consisting of methanol, ethanol, n-propanol and izopropanola.7. A process for preparing a hydrate compound of formula I, comprising the steps of: (a) dissolving the Formula I compound in water or a water-soluble organic solvent (i), and regulating pH of the solution containing the compound of Formula I (b) obtaining a hydrate containing a compound of formula I, by lowering the temperature and / or adding water-soluble organic solvent (i) (c) preparation of hydrate centrifugation or filtration (d) vacuum drying the hydrate obtained in the step (c) and regulating the water content in weight percent t Verdi vesche1. Гидрат соединения формулы I, где R представляет собой Н или катион, способный образовывать фармацевтически приемлемую соль, предпочтительно, при этом содержание воды в гидрате более 8 мас.%:2. Гидрат по п. 2, где содержание во
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